Cradle — Design Better Proteins

Cradle is an AI-assisted protein engineering platform designed to make protein design faster and more productive. By combining machine learning with a streamlined workflow, Cradle lets you design improved variants of your target protein sequence with just a few clicks.

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What Cradle does

• Generates improved protein variants guided by your defined objectives and assay measurements
• Multi-property optimization: optimize multiple attributes (e.g., activity, thermostability, solubility, expression) in a single round
• Predicts performance scores for generated sequences, helping you prioritize experiments
• Allows you to bring in lab data or start from a single starting sequence
• Private by design: data remains under your control and is not used to train models for others
• Bank-grade security and an annual flat-fee ownership model (no royalties)

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How Cradle works

1. Set up assays and objectives: Tell Cradle what you plan to measure and where those measurements should go for your project.
2. Generate sequences: Cradle designs improved sequences targeted to your objectives, with a forecast of expected performance per property.
3. Test in lab: Validate variants in your lab; the model improves as new data is collected.
4. Import lab results: Feed results back into Cradle to refine private models and inform next rounds.

Cradle emphasizes privacy and IP ownership: your sequences and experimental data stay private, under your control, and are not used to train models for other users.

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Why Cradle helps

• Accelerates time-to-market by learning from every experimental round
• Enables simultaneous optimization of multiple properties
• Keeps data private and secure with bank-grade security
• Provides owned IP with a straightforward annual fee (no royalties)

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Getting started

• Set up assays and objectives for your project
• Generate sequences with Cradle’s AI designer aligned to your objectives
• Test in the lab and import results to continuously improve the model
• Maintain control over your data and IP throughout the process

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Key Capabilities

• Protein sequence generation guided by defined objectives
• Multi-property optimization in a single round
• Performance forecasting per property
• Private data storage and ownership of IP
• Secure data handling with bank-grade security
• Flat-fee annual licensing

• AI-assisted protein variant design focused on user-defined objectives
• Multi-property optimization across enzymes, vaccines, peptides, and antibodies
• Sequence generation with performance forecasts per property
• Lab data integration: generate sequences, test in lab, and import results
• Private by design: your data is not used to train models for others
• Bank-grade security and data protection
• Royalties-free, flat annual licensing
• Easy integration into existing workflows and assays